AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test
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چکیده
منابع مشابه
AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test.
The mechanism by which lithium exerts either its anti-manic or antidepressant effects remains to be fully elucidated. Although lithium inhibits the enzyme glycogen synthase kinase-3 (GSK-3) at concentrations that are relevant for treatment of bipolar disorder, it is unclear whether GSK-3-related mechanisms are responsible for its therapeutic effects in the treatment of this disease. We report t...
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We showed previously that cAMP response element-binding protein (CREB) within the nucleus accumbens (NAc) of rats regulates immobility in the forced swim test (FST), an assay used to study depression. Because CREB regulates expression of dynorphin (which acts at -opioid receptors) in NAc neurons, these findings raised the possibility that -receptors mediate immobility behaviors in the FST. Here...
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We showed previously that cAMP response element-binding protein (CREB) within the nucleus accumbens (NAc) of rats regulates immobility in the forced swim test (FST), an assay used to study depression. Because CREB regulates expression of dynorphin (which acts at kappa-opioid receptors) in NAc neurons, these findings raised the possibility that kappa-receptors mediate immobility behaviors in the...
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ژورنال
عنوان ژورنال: The International Journal of Neuropsychopharmacology
سال: 2004
ISSN: 1461-1457,1469-5111
DOI: 10.1017/s1461145704004535